Effect of 8 Weeks of Low-Intensity Continuous Training on Plasma Adipolin, Insulin Resistance, and Weight of Fatty Fat-Filled Rats

In recent years, the rates of obesity and related illnesses have increased in the country, with 71% of Iranian women and men suffering from overweight and obesity [1]. The epidemic of obesity and the prevalence of disorders and associated illnesses have led to an increase of 30% in health care and obesity costs in obese people compared to normal weight counterparts [2]. Therefore, harm to individual health and quality of life has led researchers to study the causes and treatment of obesity as an effort to research their research. Although calorie restriction and dietary therapy are one of the main therapeutic interventions in controlling weight and obesity, exercise training with a 20-80 percent reduction in risk appetite in preventing and reducing the effects of pathologic abnormalities and improving the quality of life plays a role Have [3]. Recent studies have shown that physical activity and exercise may be due to the effect on body fat content and its secretion half-life in Reduce the risk of heart and metabolic diseases. The adipose tissue, as an active and active paracrine tissue, is involved in the synthesis and secretion of a series of hormones and adipocytokines, such as leptin, adiponectin and visfatin, not only in controlling body weight balance, but also by affecting the metabolic and inflammatory profile , Justifies the relationship between overweight and obesity with insulin resistance and diabetes [4,5]. In between, Leptin enhances insulin resistance with its proinflammatory function [6]. Adiponectin is an anti-inflammatory cytokine with anti-diabetic function [6], and visfatin also contributes to improving insulin sensitivity with its insulin-like role [7]. Often, other adipocytokines have been identified that contribute to modulating insulin resistance. Adipolin is one of these adipocytokines. Adipolin with AdiposeDerived Insulin-Sensitizing Factor (AF) is a 12th member of the family of proteins associated with C1q / TNF-related protein (CTRP), which according to its performance by Enomoto et al. [5]. The name was introduced in 2011 [5]. Adipolin (CTRP12), as adiponectin, anti-inflammatory cytokine It is mainly synthesized and released in adipose tissue and reduced in obesity, diabetes and other pathological conditions due to obesity [5,8]. Additionally, adipolin also helps to improve insulin sensitivity [5,8]; so that adipolin not only penetrates insulin-dependent pathways, but also improves insulin signalling in adipose tissue and the liver improves insulin resistance, but it also helps with insulin resistance, glucose uptake and insulin secretion following a promise [8,9] through insulin-free pathways. Adipolin was found Volume 7 Issue 5 2017